Chemicals and Drugs

Trefoil Factor-2

A 106 amino acid (12 kDa) trefoil factor that contains two trefoil domains and associates with MUCIN-6. It is expressed in the GASTROINTESTINAL TRACT by cells of BRUNNER GLANDS; PYLORIC GLANDS and mucous neck cells. It inhibits GASTROINTESTINAL MOTILITY and GASTRIC ACID secretion and may help maintain the structural integrity of gastric mucus.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A 106 amino acid (12 kDa) trefoil factor that contains two trefoil domains and associates with MUCIN-6. It is expressed in the GASTROINTESTINAL TRACT by cells of BRUNNER GLANDS; PYLORIC GLANDS and mucous neck cells. It inhibits GASTROINTESTINAL MOTILITY and GASTRIC ACID secretion and may help maintain the structural integrity of gastric mucus.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

3 entry terms
  • TFF2 Peptide
  • TFF2 Protein
  • Trefoil Factor 2

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2017 (1992)

MeSH Hierarchy

Tree Number

  1. D12.644w.937.750

AMA Style

References

  1. National Library of Medicine. Trefoil Factor-2. Medical Subject Headings (MeSH). 2026. Unique ID D000071164. http://id.nlm.nih.gov/mesh/2026/D000071164
  2. Trefoil Factor-2. In: Wikidata. https://www.wikidata.org/wiki/Q7837794