Structured Summary
Abstract
A TGF-beta subtype that was originally identified as a GLIOBLASTOMA-derived factor which inhibits the antigen-dependent growth of both helper and CYTOTOXIC T LYMPHOCYTES. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta2 and TGF-beta2 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.
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Broader headings
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Synonyms
16 entry terms
- BSC-1 Cell Growth Inhibitor
- Cartilage-Inducing Factor-B
- Glioblastoma-Derived T-Cell Suppressor Factor
- Polyergin
- Suppressor Factor, T-Cell, Glioblastoma-Derived
- TGF-beta-2
- TGF-beta2
- BSC 1 Cell Growth Inhibitor
- Cartilage Inducing Factor B
- Glioblastoma Derived T Cell Suppressor Factor
- TGF-beta2 Latency-Associated Protein
- TGF-beta2LAP
- Transforming Growth Factor beta 2 Latency Associated Peptide
- Latency-Associated Protein, TGF-beta2
- TGF beta2 Latency Associated Protein
- TGF beta2LAP
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2007(2000)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Transforming Growth Factor beta2. Medical Subject Headings (MeSH). 2026. Unique ID D053781. http://id.nlm.nih.gov/mesh/2026/D053781
- Transforming Growth Factor beta2. In: Wikidata. https://www.wikidata.org/wiki/Q24771837