Structured Summary
Abstract
A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.
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Classification
Broader headings
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MeSH Record
Synonyms
11 entry terms
- TGF-beta-1
- TGF-beta1
- Transforming Growth Factor beta I
- Transforming Growth Factor-beta1
- TGF beta 1
- TGF-beta1 Latency-Associated Protein
- TGF-beta1LAP
- Transforming Growth Factor beta 1 Latency Associated Peptide
- Latency-Associated Protein, TGF-beta1
- TGF beta1 Latency Associated Protein
- TGF beta1LAP
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2007(1992)
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AMA Style
References
- National Library of Medicine. Transforming Growth Factor beta1. Medical Subject Headings (MeSH). 2026. Unique ID D053773. http://id.nlm.nih.gov/mesh/2026/D053773
- Transforming Growth Factor beta1. In: Wikidata. https://www.wikidata.org/wiki/Q2062543