Chemicals and Drugs

Transducin

A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual excitation process. Activation of rhodopsin on the outer membrane of rod and cone cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore hyperpolarization of the rod cells.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual excitation process. Activation of rhodopsin on the outer membrane of rod and cone cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore hyperpolarization of the rod cells.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

21 entry terms
  • G-Protein, Inhibitory Gt
  • Gt, Transducin G-Protein
  • Transducin G-Protein (Gt)
  • G Protein, Inhibitory Gt
  • G-Protein Gt, Transducin
  • Gt G-Protein, Inhibitory
  • Gt, Transducin G Protein
  • Inhibitory Gt G-Protein
  • Transducin G-Protein Gt
  • Transducin, alpha Subunit
  • Transducin, beta Subunit
  • Transducin, gamma Subunit
  • alpha-Transducin
  • beta-Transducin
  • gamma-Transducin
  • alpha Subunit Transducin
  • alpha Transducin
  • beta Subunit Transducin
  • beta Transducin
  • gamma Subunit Transducin
  • gamma Transducin

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

alpha, beta and gamma transducins refer to its subunits

MeSH Record

History Note

89

MeSH Record

Previous Indexing

  • Guanine Nucleotide Regulatory Protein (1985-1988)
  • Membrane Proteins (1980-1988)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.040w.330.300.200w.800w
  2. D12.776w.157w.325.332w.940w
  3. D12.776w.476.338.200w.800w
  4. D12.776w.543w.325w.800w

AMA Style

References

  1. National Library of Medicine. Transducin. Medical Subject Headings (MeSH). 2026. Unique ID D015293. http://id.nlm.nih.gov/mesh/2026/D015293
  2. Transducin. In: Wikipedia. https://en.wikipedia.org/wiki/Transducin
  3. Transducin. In: Wikidata. https://www.wikidata.org/wiki/Q420428