Structured Summary
Abstract
A basic-helix-loop-helix transcription factor that functions as a transcriptional repressor for genes transcribed by bHLH proteins. For example, it may negatively regulate MYOGENESIS by inhibiting MyoD1 and ASH1 proteins. It is also required for the stability of FANCONI ANEMIA COMPLEMENTATION GROUP PROTEINS and their localization to the cell nucleus in response to DNA DAMAGE.
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Classification
Broader headings
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MeSH Record
Synonyms
6 entry terms
- Hairy and Enhancer of Split 1 Protein
- Hairy-Like Transcription Factor
- HES-1, Transcription Factor
- Hairy Like Transcription Factor
- Transcription Factor HES 1
- Transcription Factor, Hairy-Like
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2017
MeSH Record
Previous Indexing
- Basic Helix-Loop-Helix Transcription Factors (1994-2016)
- Homeodomain Proteins (1994-2016)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Transcription Factor HES-1. Medical Subject Headings (MeSH). 2026. Unique ID D000072056. http://id.nlm.nih.gov/mesh/2026/D000072056
- Transcription Factor HES-1. In: Wikidata. https://www.wikidata.org/wiki/Q21120590