Phenomena and Processes

Trans-Splicing

The joining of RNA from two different genes. One type of trans-splicing is the spliced leader type (primarily found in protozoans such as trypanosomes and in lower invertebrates such as nematodes) which results in the addition of a capped, noncoding, spliced leader sequence to the 5' end of mRNAs. Another type of trans-splicing is the discontinuous group II introns type (found in plant/algal chloroplasts and plant mitochondria) which results in the joining of two independently transcribed coding sequences. Both are mechanistically similar to conventional nuclear pre-mRNA cis-splicing. Mammalian cells are also capable of trans-splicing.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The joining of RNA from two different genes. One type of trans-splicing is the spliced leader type (primarily found in protozoans such as trypanosomes and in lower invertebrates such as nematodes) which results in the addition of a capped, noncoding, spliced leader sequence to the 5' end of mRNAs. Another type of trans-splicing is the discontinuous group II introns type (found in plant/algal chloroplasts and plant mitochondria) which results in the joining of two independently transcribed coding sequences. Both are mechanistically similar to conventional nuclear pre-mRNA cis-splicing. Mammalian cells are also capable of trans-splicing.

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Synonyms

7 entry terms
  • RNA Trans-Splicing
  • Trans RNA Splicing
  • Trans Splicing
  • RNA Splicing, Trans
  • RNA Trans Splicing
  • Splicing, Trans
  • Trans-Splicings, RNA

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Aspects Covered

6 allowable subheadings

Indexed with the subheadings drug effects, ethics, genetics, immunology, physiology, radiation effects.

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Indexing Annotation

note category: a physiol process taking place within the cell nucleus; do not confuse with DNA, RECOMBINANT; CLONING, MOLECULAR; or GENETIC ENGINEERING

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History Note

1999

MeSH Record

Previous Indexing

  • RNA Splicing (1982-1998)

MeSH Hierarchy

Tree Numbers

  1. G02.111.760w.700w.750w
  2. G03w.839w.700w.750w
  3. G05.308w.700w.700w.750w

AMA Style

References

  1. National Library of Medicine. Trans-Splicing. Medical Subject Headings (MeSH). 2026. Unique ID D020040. http://id.nlm.nih.gov/mesh/2026/D020040
  2. Trans-Splicing. In: Wikipedia. https://en.wikipedia.org/wiki/Trans-splicing
  3. Trans-Splicing. In: Wikidata. https://www.wikidata.org/wiki/Q468289