Chemicals and Drugs

Topoisomerase II Inhibitors

Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

15 entry terms
  • DNA Topoisomerase II Inhibitor
  • DNA Topoisomerase II Inhibitors
  • DNA Type 2 Topoisomerase Inhibitors
  • Topoisomerase 2 Inhibitors
  • Topoisomerase II Inhibitor
  • II Inhibitor, Topoisomerase
  • Inhibitor, Topoisomerase II
  • Inhibitors, Topoisomerase 2
  • Inhibitors, Topoisomerase II
  • DNA Gyrase Inhibitor
  • DNA Gyrase Inhibitors
  • Gyrase Inhibitor, DNA
  • Gyrase Inhibitors, DNA
  • Inhibitor, DNA Gyrase
  • Inhibitors, DNA Gyrase

MeSH Record

Aspects Covered

22 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2011

MeSH Record

Previous Indexing

  • DNA Gyrase/antagonists & inhibitors (1994-2002)
  • DNA Topoisomerases, Type II/antagonists & inhibitors (1994-2010)

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. Topoisomerase II Inhibitors. Medical Subject Headings (MeSH). 2026. Unique ID D059005. http://id.nlm.nih.gov/mesh/2026/D059005
  2. Topoisomerase II Inhibitors. In: Wikidata. https://www.wikidata.org/wiki/Q50377178