Chemicals and Drugs

Tolvaptan

A benzazepine derivative and selective VASOPRESSIN V2 RECEPTOR antagonist that is used to treat euvolemic and hypervolemic HYPONATREMIA. It is also used in the treatment of rapidly progressing AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE to slow the rate of cyst development and renal insufficiency.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A benzazepine derivative and selective VASOPRESSIN V2 RECEPTOR antagonist that is used to treat euvolemic and hypervolemic HYPONATREMIA. It is also used in the treatment of rapidly progressing AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE to slow the rate of cyst development and renal insufficiency.

Chemical Identity

Chemical Information

Molecular Formula
C26H25ClN2O3
Molecular Weight
448.9 g/mol
CAS Registry No.
150683-30-0
IUPAC Name
N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide
InChIKey
GYHCTFXIZSNGJT-UHFFFAOYSA-N
SMILES
CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)O)C
MeSH Unique ID
D000077602
Source
PubChem CID 216237

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

5 entry terms
  • 7-Chloro-5-hydroxy-1-(2-methyl-4-(2-methylbenzoylamino)benzoyl)2,3,4,5-tetrahydro-1H-1-benzazepine
  • OPC 41061
  • OPC-41061
  • Samsca
  • OPC41061

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1999)

MeSH Hierarchy

Tree Number

  1. D03w.633.100.079.875w

AMA Style

References

  1. National Library of Medicine. Tolvaptan. Medical Subject Headings (MeSH). 2026. Unique ID D000077602. http://id.nlm.nih.gov/mesh/2026/D000077602
  2. Tolvaptan. In: Wikipedia. https://en.wikipedia.org/wiki/Tolvaptan
  3. Tolvaptan. In: Wikidata. https://www.wikidata.org/wiki/Q426132
  4. Tolvaptan. In: PubChem Compound. CID 216237. https://pubchem.ncbi.nlm.nih.gov/compound/216237