Chemicals and Drugs

Tolcapone

A benzophenone and nitrophenol compound that acts as an inhibitor of CATECHOL O-METHYLTRANSFERASE, an enzyme involved in the metabolism of DOPAMINE and LEVODOPA. It is used in the treatment of PARKINSON DISEASE in patients for whom levodopa is ineffective or contraindicated.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A benzophenone and nitrophenol compound that acts as an inhibitor of CATECHOL O-METHYLTRANSFERASE, an enzyme involved in the metabolism of DOPAMINE and LEVODOPA. It is used in the treatment of PARKINSON DISEASE in patients for whom levodopa is ineffective or contraindicated.

Chemical Identity

Chemical Information

Molecular Formula
C14H11NO5
Molecular Weight
273.24 g/mol
CAS Registry No.
134308-13-7
IUPAC Name
(3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone
InChIKey
MIQPIUSUKVNLNT-UHFFFAOYSA-N
SMILES
CC1=CC=C(C=C1)C(=O)C2=CC(=C(C(=C2)O)O)[N+](=O)[O-]
MeSH Unique ID
D000077867
Source
PubChem CID 4659569

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • 3,4-Dihydroxy-5'-methyl-5-nitrobenzophenone
  • Ro 40-7592
  • Ro-40-7592
  • SOM0226
  • Tasmar
  • 3,4 Dihydroxy 5' methyl 5 nitrobenzophenone
  • Ro 40 7592
  • Ro 407592
  • Ro407592

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1990)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.426w.559w.389.134.875w
  2. D02w.455w.426w.559w.389.657w.566w.845w
  3. D02w.522w.223.875w
  4. D02w.640w.743w.845w

AMA Style

References

  1. National Library of Medicine. Tolcapone. Medical Subject Headings (MeSH). 2026. Unique ID D000077867. http://id.nlm.nih.gov/mesh/2026/D000077867
  2. Tolcapone. In: Wikipedia. https://en.wikipedia.org/wiki/Tolcapone
  3. Tolcapone. In: Wikidata. https://www.wikidata.org/wiki/Q413840
  4. Tolcapone. In: PubChem Compound. CID 4659569. https://pubchem.ncbi.nlm.nih.gov/compound/4659569