Structured Summary
Abstract
A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
MeSH Record
Classification
Narrower headings
Related Concepts
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
17 entry terms
- Alteplase
- Plasminogen Activator, Tissue-Type
- T-Plasminogen Activator
- TTPA
- Tisokinase
- Tissue Activator D-44
- Tissue-Type Plasminogen Activator
- Plasminogen Activator, Tissue
- Plasminogen Activator, Tissue Type
- T Plasminogen Activator
- Tissue Activator D 44
- Tissue Type Plasminogen Activator
- Actilyse
- Activase
- Lysatec rt-PA
- Lysatec rt PA
- Lysatec rtPA
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
98(86)
MeSH Record
Previous Indexing
- Enzyme Activation (1974-1975)
- Peptide Hydrolases (1975)
- Plasminogen Activators (1976-1985)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Tissue Plasminogen Activator. Medical Subject Headings (MeSH). 2026. Unique ID D010959. http://id.nlm.nih.gov/mesh/2026/D010959
- Tissue Plasminogen Activator. In: Wikidata. https://www.wikidata.org/wiki/Q24738954