Phenomena and Processes

Tissue Distribution

Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

3 entry terms
  • Distribution, Tissue
  • Distributions, Tissue
  • Tissue Distributions

MeSH Record

Aspects Covered

6 allowable subheadings

Indexed with the subheadings drug effects, ethics, genetics, immunology, physiology, radiation effects.

MeSH Record

Indexing Annotation

general only: not a substitute for organ /metab or organ /chem; usually NIM; coordinate with substance /pharmacokin or /metab

MeSH Record

History Note

78

MeSH Record

Previous Indexing

  • Organ Specificity (1966-1977)

MeSH Hierarchy

Tree Numbers

  1. G03w.787w.917
  2. G07.690.725w.949

MeSH Record

NLM Classification

QV 38

AMA Style

References

  1. National Library of Medicine. Tissue Distribution. Medical Subject Headings (MeSH). 2026. Unique ID D014018. http://id.nlm.nih.gov/mesh/2026/D014018
  2. Tissue Distribution. In: Wikidata. https://www.wikidata.org/wiki/Q71129604