Chemicals and Drugs

Timolol

A beta-adrenergic antagonist that is similar in action to PROPRANOLOL; the levo-isomer is more active. Timolol has been proposed as an anti-hypertensive, anti-arrhythmic, anti-angina, and anti-glaucoma agent. It is also used in the treatment of MIGRAINE DISORDERS and tremor.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A beta-adrenergic antagonist that is similar in action to PROPRANOLOL; the levo-isomer is more active. Timolol has been proposed as an anti-hypertensive, anti-arrhythmic, anti-angina, and anti-glaucoma agent. It is also used in the treatment of MIGRAINE DISORDERS and tremor.

Chemical Identity

Chemical Information

Molecular Formula
C13H24N4O3S
Molecular Weight
316.42 g/mol
CAS Registry No.
26839-75-8
IUPAC Name
(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
InChIKey
BLJRIMJGRPQVNF-JTQLQIEISA-N
SMILES
CC(C)(C)NC[C@@H](COC1=NSN=C1N2CCOCC2)O
MeSH Unique ID
D013999
Source
PubChem CID 33624

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

16 entry terms
  • (S)-1-((1,1-Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadazol-3-yl)oxy)-2-propanol
  • 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, (S)-
  • Blocadren
  • L-714,465
  • MK-950
  • Optimol
  • Timacar
  • Timolol Hemihydrate
  • Timolol Maleate
  • Timolol Maleate, (1:1) Salt
  • Timoptic
  • Timoptol
  • L 714,465
  • L714,465
  • MK 950
  • MK950

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

1984 (1977)

MeSH Record

Previous Indexing

  • Amino Alcohols (1972-1973)
  • Morpholines (1972-1975)
  • Propanolamines (1974-1976)
  • Thiadiazoles (1972-1976)

MeSH Hierarchy

Tree Numbers

  1. D02w.033w.100w.624w.915w
  2. D02w.033w.755.624w.915w
  3. D02w.092w.063w.624w.915w
  4. D02w.886w.675.867w.768w
  5. D03w.383.129w.708.867w.768w
  6. D03w.383.533.640.775w

AMA Style

References

  1. National Library of Medicine. Timolol. Medical Subject Headings (MeSH). 2026. Unique ID D013999. http://id.nlm.nih.gov/mesh/2026/D013999
  2. Timolol. In: Wikipedia. https://en.wikipedia.org/wiki/Timolol
  3. Timolol. In: Wikidata. https://www.wikidata.org/wiki/Q413994
  4. Timolol. In: PubChem Compound. CID 33624. https://pubchem.ncbi.nlm.nih.gov/compound/33624