Chemicals and Drugs

Tigecycline

A tetracycline derivative that acts as a protein synthesis inhibitor. It is used as an antibacterial agent for the systemic treatment of complicated skin and intra-abdominal infections. It is also used for the treatment of community-acquired pneumonia.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A tetracycline derivative that acts as a protein synthesis inhibitor. It is used as an antibacterial agent for the systemic treatment of complicated skin and intra-abdominal infections. It is also used for the treatment of community-acquired pneumonia.

Chemical Identity

Chemical Information

Molecular Formula
C29H39N5O8
Molecular Weight
585.6 g/mol
IUPAC Name
N-[(5aR,6aS,7S,9Z,10aS)-9-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-1,10a,12-trihydroxy-8,10,11-trioxo-5a,6,6a,7-tetrahydro-5H-tetracen-2-yl]-2-(tert-butylamino)acetamide
InChIKey
ZXGBRIBPJBHLMO-SBMFAFPZSA-N
SMILES
CC(C)(C)NCC(=O)NC1=CC(=C2C[C@H]3C[C@H]4[C@@H](C(=O)/C(=C(\N)/O)/C(=O)[C@]4(C(=O)C3=C(C2=C1O)O)O)N(C)C)N(C)C
MeSH Unique ID
D000078304
Source
PubChem CID 5282044

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

6 entry terms
  • 9-(tert-Butylglycylamido)minocycline
  • TBG-MINO
  • GAR 936
  • GAR-936
  • Tygacil
  • GAR936

MeSH Record

Aspects Covered

26 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1999)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.426w.559w.847w.562.900w.937w
  2. D04w.615w.562.900w.937w

AMA Style

References

  1. National Library of Medicine. Tigecycline. Medical Subject Headings (MeSH). 2026. Unique ID D000078304. http://id.nlm.nih.gov/mesh/2026/D000078304
  2. Tigecycline. In: Wikipedia. https://en.wikipedia.org/wiki/Tigecycline
  3. Tigecycline. In: Wikidata. https://www.wikidata.org/wiki/Q420595
  4. Tigecycline. In: PubChem Compound. CID 5282044. https://pubchem.ncbi.nlm.nih.gov/compound/5282044