Chemicals and Drugs

Thyrotropin-Releasing Hormone

A tripeptide that stimulates the release of THYROTROPIN and PROLACTIN. It is synthesized by the neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, TRH (was called TRF) stimulates the release of TSH and PRL from the ANTERIOR PITUITARY GLAND.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A tripeptide that stimulates the release of THYROTROPIN and PROLACTIN. It is synthesized by the neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, TRH (was called TRF) stimulates the release of TSH and PRL from the ANTERIOR PITUITARY GLAND.

Chemical Identity

Chemical Information

Molecular Formula
C16H22N6O4
Molecular Weight
362.38 g/mol
CAS Registry No.
24305-27-9
IUPAC Name
(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
InChIKey
XNSAINXGIQZQOO-SRVKXCTJSA-N
SMILES
C1C[C@H](N(C1)C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@@H]3CCC(=O)N3)C(=O)N
MeSH Unique ID
D013973
Source
PubChem CID 638678

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

26 entry terms
  • Protirelin
  • Thyrotropin-Releasing Factor
  • Thyrotropin Releasing Factor
  • Thyrotropin Releasing Hormone
  • Abbott-38579
  • Antepan
  • Proterelin Tartrate
  • Proterelin Tartrate Hydrate
  • Protirelin Tartrate (1:1)
  • Relefact TRH
  • Stimu-TSH
  • TRH Ferring
  • TRH Prem
  • Thypinone
  • Thyroliberin
  • Thyroliberin TRH Merck
  • Thyrotropin-Releasing Hormone Tartrate
  • Abbott 38579
  • Abbott38579
  • Hydrate, Proterelin Tartrate
  • Prem, TRH
  • Stimu TSH
  • StimuTSH
  • TRH, Relefact
  • Tartrate Hydrate, Proterelin
  • Thyrotropin Releasing Hormone Tartrate

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2006(1968)

MeSH Record

Previous Indexing

  • Hypothalamo-Hypophyseal System/physiology (1966-1967)
  • Thyrotropin/biosynthesis (1966-1967)
  • Thyrotropin/metabolism (1966-1967)

MeSH Hierarchy

Tree Numbers

  1. D06.472w.699w.327.740.880w
  2. D12.644w.400w.400.740.880w
  3. D12.644w.456w.837w
  4. D12.644w.548w.365.740.880w
  5. D12.776w.631w.650w.405.740.880w
  6. D12.776w.631w.650w.810w

MeSH Record

NLM Classification

WK 515

AMA Style

References

  1. National Library of Medicine. Thyrotropin-Releasing Hormone. Medical Subject Headings (MeSH). 2026. Unique ID D013973. http://id.nlm.nih.gov/mesh/2026/D013973
  2. Thyrotropin-Releasing Hormone. In: Wikipedia. https://en.wikipedia.org/wiki/Thyrotropin-releasing_hormone
  3. Thyrotropin-Releasing Hormone. In: Wikidata. https://www.wikidata.org/wiki/Q12910980
  4. Thyrotropin-Releasing Hormone. In: PubChem Compound. CID 638678. https://pubchem.ncbi.nlm.nih.gov/compound/638678