Chemicals and Drugs

Thymopentin

Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. It is an immunomodulator which has been studied for possible use in the treatment of rheumatoid arthritis, AIDS, and other primary immunodeficiencies.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. It is an immunomodulator which has been studied for possible use in the treatment of rheumatoid arthritis, AIDS, and other primary immunodeficiencies.

Chemical Identity

Chemical Information

Molecular Formula
C30H49N9O9
Molecular Weight
679.8 g/mol
CAS Registry No.
69558-55-0
IUPAC Name
(3S)-3-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-[[(2S)-1-[[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
InChIKey
PSWFFKRAVBDQEG-YGQNSOCVSA-N
SMILES
CC(C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)N
MeSH Unique ID
D016305
Source
PubChem CID 451417

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

4 entry terms
  • TP-5
  • Thymopoietin Pentapeptide
  • Pentapeptide, Thymopoietin
  • Timunox

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91

MeSH Record

Previous Indexing

  • Oligopeptides (1980-1981)
  • Peptide Fragments (1981-1990)
  • Thymopoietins (1981-1990)

MeSH Hierarchy

Tree Number

  1. D06.472w.910.800w.850w

AMA Style

References

  1. National Library of Medicine. Thymopentin. Medical Subject Headings (MeSH). 2026. Unique ID D016305. http://id.nlm.nih.gov/mesh/2026/D016305
  2. Thymopentin. In: Wikipedia. https://en.wikipedia.org/wiki/Thymopentin
  3. Thymopentin. In: Wikidata. https://www.wikidata.org/wiki/Q7799637
  4. Thymopentin. In: PubChem Compound. CID 451417. https://pubchem.ncbi.nlm.nih.gov/compound/451417