Chemicals and Drugs

Thymine DNA Glycosylase

An enzyme that removes THYMINE and URACIL bases mispaired with GUANINE through hydrolysis of their N-glycosidic bond. These mispaired nucleotides generally occur through the hydrolytic DEAMINATION of 5-METHYLCYTOSINE to thymine.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An enzyme that removes THYMINE and URACIL bases mispaired with GUANINE through hydrolysis of their N-glycosidic bond. These mispaired nucleotides generally occur through the hydrolytic DEAMINATION of 5-METHYLCYTOSINE to thymine.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

8 entry terms
  • G-T Mismatch-Specific Thymine DNA Glycosylase
  • Thymine Glycol DNA Glycosylase
  • Thymine Glycol Glycosylase
  • DNA Glycosylase, Thymine
  • G T Mismatch Specific Thymine DNA Glycosylase
  • Glycol Glycosylase, Thymine
  • Glycosylase, Thymine DNA
  • Glycosylase, Thymine Glycol

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2004; use THYMINE DNA GLYCOSYLASE (NM) 1991-2003

MeSH Record

Previous Indexing

  • Endodeoxyribonucleases (1991-2003)

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. Thymine DNA Glycosylase. Medical Subject Headings (MeSH). 2026. Unique ID D044502. http://id.nlm.nih.gov/mesh/2026/D044502
  2. Thymine DNA Glycosylase. In: Wikidata. https://www.wikidata.org/wiki/Q21108145