Structured Summary
Abstract
An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin. Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. Also, it has been studied for its use as a potential regulator of tumor growth and metastasis.
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Classification
Broader headings
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Synonyms
1 entry terms
- TSP-1
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
Indexing Annotation
a membrane glycoprotein
MeSH Record
History Note
98; see THROMBOSPONDIN (NM) 1991-97
MeSH Record
Previous Indexing
- Membrane Glycoproteins (1993-1997)
- Platelet Membrane Glycoproteins (1991-1993)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Thrombospondin 1. Medical Subject Headings (MeSH). 2026. Unique ID D019700. http://id.nlm.nih.gov/mesh/2026/D019700
- Thrombospondin 1. In: Wikidata. https://www.wikidata.org/wiki/Q24781494