Chemicals and Drugs

Thiotepa

A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).

Chemical Identity

Chemical Information

Molecular Formula
C6H12N3PS
Molecular Weight
189.22 g/mol
CAS Registry No.
52-24-4
IUPAC Name
tris(aziridin-1-yl)-sulfanylidene-lambda5-phosphane
InChIKey
FOCVUCIESVLUNU-UHFFFAOYSA-N
SMILES
C1CN1P(=S)(N2CC2)N3CC3
MeSH Unique ID
D013852
Source
PubChem CID 5453

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

14 entry terms
  • Thio-Tepa
  • Thiophosphamide
  • Triethylenethiophosphoramide
  • Tris(1-aziridinyl)phosphine Sulfide
  • Thio Tepa
  • AI3-24916
  • Girostan
  • NSC-6396
  • Tespa
  • Tespamin
  • AI3 24916
  • AI324916
  • NSC 6396
  • NSC6396

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

92; was THIO-TEPA 1963-91; THIOTEPA was see THIO-TEPA 1977-91

MeSH Hierarchy

Tree Numbers

  1. D02w.705w.672w.875w
  2. D03w.383.097.217w.935.960w

MeSH Record

NLM Classification

QV 269

AMA Style

References

  1. National Library of Medicine. Thiotepa. Medical Subject Headings (MeSH). 2026. Unique ID D013852. http://id.nlm.nih.gov/mesh/2026/D013852
  2. Thiotepa. In: Wikipedia. https://en.wikipedia.org/wiki/Thiotepa
  3. Thiotepa. In: Wikidata. https://www.wikidata.org/wiki/Q416507
  4. Thiotepa. In: PubChem Compound. CID 5453. https://pubchem.ncbi.nlm.nih.gov/compound/5453