Chemicals and Drugs

Thioredoxins

Hydrogen-donating proteins that participates in a variety of biochemical reactions including ribonucleotide reduction and reduction of PEROXIREDOXINS. Thioredoxin is oxidized from a dithiol to a disulfide when acting as a reducing cofactor. The disulfide form is then reduced by NADPH in a reaction catalyzed by THIOREDOXIN REDUCTASE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Hydrogen-donating proteins that participates in a variety of biochemical reactions including ribonucleotide reduction and reduction of PEROXIREDOXINS. Thioredoxin is oxidized from a dithiol to a disulfide when acting as a reducing cofactor. The disulfide form is then reduced by NADPH in a reaction catalyzed by THIOREDOXIN REDUCTASE.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

5 entry terms
  • Thioredoxin
  • Thioredoxin 1
  • Thioredoxin 2
  • Thioredoxin-1
  • Thioredoxin-2

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2008(1975)

MeSH Record

Previous Indexing

  • Bacterial Proteins (1968-1974)

MeSH Hierarchy

Tree Number

  1. D12.776w.915

MeSH Record

NLM Classification

QU 55

AMA Style

References

  1. National Library of Medicine. Thioredoxins. Medical Subject Headings (MeSH). 2026. Unique ID D013879. http://id.nlm.nih.gov/mesh/2026/D013879
  2. Thioredoxins. In: Wikidata. https://www.wikidata.org/wiki/Q24777689