Chemicals and Drugs

Thiamine Pyrophosphate

The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMPLEX and the KETOGLUTARATE DEHYDROGENASE COMPLEX.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMPLEX and the KETOGLUTARATE DEHYDROGENASE COMPLEX.

Chemical Identity

Chemical Information

Molecular Formula
C12H19N4O7P2S+
Molecular Weight
425.32 g/mol
CAS Registry No.
136-08-3
IUPAC Name
2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethyl phosphono hydrogen phosphate
InChIKey
AYEKOFBPNLCAJY-UHFFFAOYSA-O
SMILES
CC1=C(SC=[N+]1CC2=CN=C(N=C2N)C)CCOP(=O)(O)OP(=O)(O)O
MeSH Unique ID
D013835
Source
PubChem CID 1132

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

4 entry terms
  • Cocarboxylase
  • Thiamine Diphosphate
  • Pyrophosphate, Thiamine
  • Berolase

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

do not confuse with THIAMINE PYROPHOSPHATASE; deficiency: coordinate THIAMINE PYROPHOSPHATE /defic (IM) with THIAMINE DEFICIENCY (IM)

MeSH Hierarchy

Tree Numbers

  1. D02w.886w.675.900w.702w
  2. D03w.383.129w.708.900w.702w
  3. D03w.383.742.795w.702w
  4. D08.211w.878w

MeSH Record

NLM Classification

QU 135

AMA Style

References

  1. National Library of Medicine. Thiamine Pyrophosphate. Medical Subject Headings (MeSH). 2026. Unique ID D013835. http://id.nlm.nih.gov/mesh/2026/D013835
  2. Thiamine Pyrophosphate. In: Wikipedia. https://en.wikipedia.org/wiki/Thiamine_pyrophosphate
  3. Thiamine Pyrophosphate. In: Wikidata. https://www.wikidata.org/wiki/Q415003
  4. Thiamine Pyrophosphate. In: PubChem Compound. CID 1132. https://pubchem.ncbi.nlm.nih.gov/compound/1132