Structured Summary
Abstract
Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.
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Classification
Broader headings
Related Concepts
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Drug Class
Pharmacological Action
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See Also
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Synonyms
7 entry terms
- Clostridium tetani Toxin
- Tetanus Toxins
- Toxin, Clostridium tetani
- Toxin, Tetanus
- Toxins, Tetanus
- Clostridial Neurotoxin
- Neurotoxin, Clostridial
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Aspects Covered
27 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
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Indexing Annotation
/antag permitted but consider also TETANUS ANTITOXIN
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History Note
65
MeSH Hierarchy
Tree Numbers
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NLM Classification
WC 320
AMA Style
References
- National Library of Medicine. Tetanus Toxin. Medical Subject Headings (MeSH). 2026. Unique ID D013744. http://id.nlm.nih.gov/mesh/2026/D013744
- Tetanus Toxin. In: Wikipedia. https://en.wikipedia.org/wiki/Tetanus_toxin
- Tetanus Toxin. In: Wikidata. https://www.wikidata.org/wiki/Q411288