Chemicals and Drugs

Terfenadine

A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.

Chemical Identity

Chemical Information

Molecular Formula
C32H41NO2
Molecular Weight
471.7 g/mol
CAS Registry No.
50679-08-8
IUPAC Name
1-(4-tert-butylphenyl)-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butan-1-ol
InChIKey
GUGOEEXESWIERI-UHFFFAOYSA-N
SMILES
CC(C)(C)C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O
MeSH Unique ID
D016593
Source
PubChem CID 5405

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

21 entry terms
  • Terfenidine
  • alpha-(4-(1,1-Dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperdinebutanol
  • Balkis Saft Spezial
  • Cyater
  • Hisfedin
  • RMI-9918
  • Rapidal
  • Seldane
  • Teldane
  • Terfedura
  • Terfemundin
  • Terfenadin AL
  • Terfenadin Heumann
  • Terfenadin Stada
  • Terfenadin Von Ct
  • Terfenadin-Ratiopharm
  • Ternadin
  • Triludan
  • RMI 9918
  • RMI9918
  • Terfenadin Ratiopharm

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

92; was TERFENADINE (NM) 1978-91

MeSH Record

Previous Indexing

  • Benzhydryl Compounds (1975-1991)
  • Histamine H1 Receptor Blockaders (1966-1991)
  • Piperidines (1966-1991)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.426w.559w.389.115w.800w
  2. D03w.383.621.855w

AMA Style

References

  1. National Library of Medicine. Terfenadine. Medical Subject Headings (MeSH). 2026. Unique ID D016593. http://id.nlm.nih.gov/mesh/2026/D016593
  2. Terfenadine. In: Wikipedia. https://en.wikipedia.org/wiki/Terfenadine
  3. Terfenadine. In: Wikidata. https://www.wikidata.org/wiki/Q417909
  4. Terfenadine. In: PubChem Compound. CID 5405. https://pubchem.ncbi.nlm.nih.gov/compound/5405