Chemicals and Drugs

Tacrine

A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.

Chemical Identity

Chemical Information

Molecular Formula
C13H14N2
Molecular Weight
198.26 g/mol
CAS Registry No.
321-64-2
IUPAC Name
1,2,3,4-tetrahydroacridin-9-amine
InChIKey
YLJREFDVOIBQDA-UHFFFAOYSA-N
SMILES
C1CCC2=NC3=CC=CC=C3C(=C2C1)N
MeSH Unique ID
D013619
Source
PubChem CID 1935

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • 1,2,3,4-Tetrahydro-9-acridinamine
  • 1,2,3,4-Tetrahydroaminoacridine
  • 9-Amino-1,2,3,4-Tetrahydroacridine
  • Tetrahydroaminoacridine
  • Cognex
  • Romotal
  • THA
  • Tacrine Hydrochloride
  • Tenakrin

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(75); was see under AMINOACRIDINES 1984-90; was see under ACRIDINES 1975-83

MeSH Record

Previous Indexing

  • Acridines (1969-1974)
  • Amines (1972-1974)

MeSH Hierarchy

Tree Number

  1. D03w.633.300.046w.250w.900w

AMA Style

References

  1. National Library of Medicine. Tacrine. Medical Subject Headings (MeSH). 2026. Unique ID D013619. http://id.nlm.nih.gov/mesh/2026/D013619
  2. Tacrine. In: Wikipedia. https://en.wikipedia.org/wiki/Tacrine
  3. Tacrine. In: Wikidata. https://www.wikidata.org/wiki/Q421076
  4. Tacrine. In: PubChem Compound. CID 1935. https://pubchem.ncbi.nlm.nih.gov/compound/1935