Structured Summary
Abstract
A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.
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Classification
Broader headings
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MeSH Record
Synonyms
11 entry terms
- Apo-2 Ligand
- Apo-2L Protein
- CD253 Antigen
- TNF Superfamily, Member 10
- TRAIL Protein
- Tumor Necrosis Factor Ligand Superfamily Member 10
- Antigen, CD253
- Apo 2 Ligand
- Apo 2L Protein
- Apoptosis-Inducing Ligand, TNF-Related
- TNF Related Apoptosis Inducing Ligand
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2007(2005)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. TNF-Related Apoptosis-Inducing Ligand. Medical Subject Headings (MeSH). 2026. Unique ID D053221. http://id.nlm.nih.gov/mesh/2026/D053221
- TNF-Related Apoptosis-Inducing Ligand. In: Wikipedia. https://en.wikipedia.org/wiki/TRAIL
- TNF-Related Apoptosis-Inducing Ligand. In: Wikidata. https://www.wikidata.org/wiki/Q424394