Chemicals and Drugs

TATA-Box Binding Protein

A general transcription factor that plays a major role in the activation of eukaryotic genes transcribed by RNA POLYMERASES. It binds specifically to the TATA BOX promoter element, which lies close to the position of transcription initiation in RNA transcribed by RNA POLYMERASE II. Although considered a principal component of TRANSCRIPTION FACTOR TFIID it also takes part in general transcription factor complexes involved in RNA POLYMERASE I and RNA POLYMERASE III transcription.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A general transcription factor that plays a major role in the activation of eukaryotic genes transcribed by RNA POLYMERASES. It binds specifically to the TATA BOX promoter element, which lies close to the position of transcription initiation in RNA transcribed by RNA POLYMERASE II. Although considered a principal component of TRANSCRIPTION FACTOR TFIID it also takes part in general transcription factor complexes involved in RNA POLYMERASE I and RNA POLYMERASE III transcription.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

7 entry terms
  • RNA Polymerase II TATA-Binding Protein
  • TATA-Binding Protein
  • TATA-Box-Binding Protein
  • Transcription Factor TBP
  • RNA Polymerase II TATA Binding Protein
  • TATA Binding Protein
  • TATA Box Binding Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003; use TATA-BOX BINDING PROTEIN (NM) 1992-2002

MeSH Record

Previous Indexing

  • DNA-Binding Proteins (1992-2002)
  • Transcription Factors (1992-2002)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.260w.775w.374
  2. D12.776w.260w.775w.875.750w.500
  3. D12.776w.930w.930w.374
  4. D12.776w.930w.930w.875.750w.500

AMA Style

References

  1. National Library of Medicine. TATA-Box Binding Protein. Medical Subject Headings (MeSH). 2026. Unique ID D035181. http://id.nlm.nih.gov/mesh/2026/D035181
  2. TATA-Box Binding Protein. In: Wikidata. https://www.wikidata.org/wiki/Q24738673