Diseases

Systemic Inflammatory Response Syndrome

A systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees C or HYPOTHERMIA <36 degrees C; (2) TACHYCARDIA >90 beat/minute; (3) tachypnea >24 breaths/minute; (4) LEUKOCYTOSIS >12,000 cells/cubic mm or 10% immature forms. While usually related to infection, SIRS can also be associated with noninfectious insults such as TRAUMA; BURNS; or PANCREATITIS. If infection is involved, a patient with SIRS is said to have SEPSIS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees C or HYPOTHERMIA <36 degrees C; (2) TACHYCARDIA >90 beat/minute; (3) tachypnea >24 breaths/minute; (4) LEUKOCYTOSIS >12,000 cells/cubic mm or 10% immature forms. While usually related to infection, SIRS can also be associated with noninfectious insults such as TRAUMA; BURNS; or PANCREATITIS. If infection is involved, a patient with SIRS is said to have SEPSIS.

MeSH Record

Classification

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MeSH Record

See Also

MeSH Record

Synonyms

5 entry terms
  • Inflammatory Response Syndrome, Systemic
  • Sepsis Syndrome
  • Sepsis Syndromes
  • Syndrome, Sepsis
  • Syndromes, Sepsis

MeSH Record

Aspects Covered

36 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, transmission, urine, veterinary, virology.

MeSH Record

Indexing Annotation

systemic inflammatory response syndrome associated with infection = SEPSIS or specifics

MeSH Record

History Note

2007 (1995)

MeSH Hierarchy

Tree Numbers

  1. C23.550.470w.790w
  2. C23.550.835w.900w

MeSH Record

NLM Classification

QZ 150

AMA Style

References

  1. National Library of Medicine. Systemic Inflammatory Response Syndrome. Medical Subject Headings (MeSH). 2026. Unique ID D018746. http://id.nlm.nih.gov/mesh/2026/D018746
  2. Systemic Inflammatory Response Syndrome. In: Wikipedia. https://en.wikipedia.org/wiki/Systemic_inflammatory_response_syndrome
  3. Systemic Inflammatory Response Syndrome. In: Wikidata. https://www.wikidata.org/wiki/Q776030