Structured Summary
Abstract
A family of synaptic vesicle-associated proteins involved in the short-term regulation of NEUROTRANSMITTER release. Synapsin I, the predominant member of this family, links SYNAPTIC VESICLES to ACTIN FILAMENTS in the presynaptic nerve terminal. These interactions are modulated by the reversible PHOSPHORYLATION of synapsin I through various signal transduction pathways. The protein is also a substrate for cAMP- and CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. It is believed that these functional properties are also shared by synapsin II.
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Synonyms
4 entry terms
- Synapsin
- Synapsin I
- Synapsin II
- Synapsin III
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
1992; use SYNAPSINS (NM) 1981-1991
MeSH Record
Previous Indexing
- Nerve Tissue Proteins (1966-1991)
- Neuropeptides (1987-1991)
- Phosphoproteins (1970-1991)
MeSH Hierarchy
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AMA Style
References
- National Library of Medicine. Synapsins. Medical Subject Headings (MeSH). 2026. Unique ID D016704. http://id.nlm.nih.gov/mesh/2026/D016704
- Synapsins. In: Wikipedia. https://en.wikipedia.org/wiki/Synapsin
- Synapsins. In: Wikidata. https://www.wikidata.org/wiki/Q24769435