Chemicals and Drugs

Superhelical DNA

Circular duplex DNA isolated from viruses, bacteria and mitochondria in supercoiled or supertwisted form. This superhelical DNA is endowed with free energy. During transcription, the magnitude of RNA initiation is proportional to the DNA superhelicity.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Circular duplex DNA isolated from viruses, bacteria and mitochondria in supercoiled or supertwisted form. This superhelical DNA is endowed with free energy. During transcription, the magnitude of RNA initiation is proportional to the DNA superhelicity.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

5 entry terms
  • DNA, Supercoiled
  • DNA, Superhelical
  • DNA, Supertwisted
  • Supercoiled DNA
  • Supertwisted DNA

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

IM; /drug eff /ultrastruct permitted

MeSH Record

History Note

78

MeSH Record

Previous Indexing

  • DNA (1966-1977)
  • DNA, Circular (1973-1977)

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. Superhelical DNA. Medical Subject Headings (MeSH). 2026. Unique ID D004278. http://id.nlm.nih.gov/mesh/2026/D004278
  2. Superhelical DNA. In: Wikipedia. https://en.wikipedia.org/wiki/DNA_supercoil
  3. Superhelical DNA. In: Wikidata. https://www.wikidata.org/wiki/Q412639