Chemicals and Drugs

Sulfasalazine

A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)

Chemical Identity

Chemical Information

Molecular Formula
C18H14N4O5S
Molecular Weight
398.4 g/mol
IUPAC Name
(3E)-6-oxo-3-[[4-(pyridin-2-ylsulfamoyl)phenyl]hydrazinylidene]cyclohexa-1,4-diene-1-carboxylic acid
InChIKey
OQANPHBRHBJGNZ-FYJGNVAPSA-N
SMILES
C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N/N=C/3\C=CC(=O)C(=C3)C(=O)O
MeSH Unique ID
D012460
Source
PubChem CID 5353980

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

20 entry terms
  • Salazosulfapyridine
  • Salicylazosulfapyridine
  • Sulphasalazine
  • Asulfidine
  • Azulfadine
  • Azulfidine
  • Azulfidine EN
  • Colo-Pleon
  • Pleon
  • Pyralin EN
  • Salazopyrin
  • Sulfasalazin medac
  • Sulfasalazin-Heyl
  • Sulfasalazine FNA
  • Ucine
  • Ulcol
  • ratio-Sulfasalazine
  • Colo Pleon
  • Sulfasalazin Heyl
  • ratio Sulfasalazine

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

1995 (1963)

MeSH Hierarchy

Tree Numbers

  1. D02w.065w.884w.730w
  2. D02w.886w.590w.700w.730w

AMA Style

References

  1. National Library of Medicine. Sulfasalazine. Medical Subject Headings (MeSH). 2026. Unique ID D012460. http://id.nlm.nih.gov/mesh/2026/D012460
  2. Sulfasalazine. In: Wikipedia. https://en.wikipedia.org/wiki/Sulfasalazine
  3. Sulfasalazine. In: Wikidata. https://www.wikidata.org/wiki/Q420035
  4. Sulfasalazine. In: PubChem Compound. CID 5353980. https://pubchem.ncbi.nlm.nih.gov/compound/5353980