Structured Summary
Abstract
An enzyme that plays a role in the GLUTAMATE and butanoate metabolism pathways by catalyzing the oxidation of succinate semialdehyde to SUCCINATE using NAD+ as a coenzyme. Deficiency of this enzyme, causes 4-hydroxybutyricaciduria, a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA).
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Synonyms
8 entry terms
- NAD(+)-Dependent Succinic Semialdehyde Dehydrogenase
- Succinate Semialdehyde Dehydrogenase
- Succinic Semialdehyde Dehydrogenase
- Dehydrogenase, Succinate Semialdehyde
- Dehydrogenase, Succinate-Semialdehyde
- Dehydrogenase, Succinic Semialdehyde
- Semialdehyde Dehydrogenase, Succinate
- Semialdehyde Dehydrogenase, Succinic
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2006(1980); use ALDEHYDE OXIDREDUCTASES 1977-1979
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AMA Style
References
- National Library of Medicine. Succinate-Semialdehyde Dehydrogenase. Medical Subject Headings (MeSH). 2026. Unique ID D050644. http://id.nlm.nih.gov/mesh/2026/D050644
- Succinate-Semialdehyde Dehydrogenase. In: Wikipedia. https://en.wikipedia.org/wiki/Succinate-semialdehyde_dehydrogenase
- Succinate-Semialdehyde Dehydrogenase. In: Wikidata. https://www.wikidata.org/wiki/Q3976579