Chemicals and Drugs

Substance P

An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.

Chemical Identity

Chemical Information

Molecular Formula
C63H98N18O13S
Molecular Weight
1347.6 g/mol
CAS Registry No.
33507-63-0
IUPAC Name
(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide
InChIKey
ADNPLDHMAVUMIW-CUZNLEPHSA-N
SMILES
CC(C)C[C@@H](C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCN=C(N)N)N
MeSH Unique ID
D013373
Source
PubChem CID 36511

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

6 entry terms
  • Euler-Gaddum Substance P
  • SP(1-11)
  • Euler Gaddum Substance P
  • Substance P, Euler-Gaddum
  • Hypothalamic Substance P
  • Substance P, Hypothalamic

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

73(65); was see under PEPTIDES 1963-72; EULER-GADDUM SUBSTANCE P was see SUBSTANCE P 1973-92; HYPOTHALAMIC SUBSTANCE P was see SUBSTANCE P 1977-92

MeSH Hierarchy

Tree Numbers

  1. D12.644w.276.812w.900w.866w
  2. D12.644w.400w.800w.750w
  3. D12.644w.456w.800w.866w
  4. D12.776w.467.812w.900w.866w
  5. D12.776w.631w.650w.800w.750w
  6. D23.469.050w.375w.850w.890w
  7. D23.529.812w.900w.866w

AMA Style

References

  1. National Library of Medicine. Substance P. Medical Subject Headings (MeSH). 2026. Unique ID D013373. http://id.nlm.nih.gov/mesh/2026/D013373
  2. Substance P. In: Wikipedia. https://en.wikipedia.org/wiki/Substance_P
  3. Substance P. In: Wikidata. https://www.wikidata.org/wiki/Q411041
  4. Substance P. In: PubChem Compound. CID 36511. https://pubchem.ncbi.nlm.nih.gov/compound/36511