Structured Summary
Abstract
An ATP binding cassette sub-family A transporter that translocates 11-cis and all-trans isomers of N-retinylidene-phosphatidylethanolamine (RETINOIDS) from the extracellular surface to the cytoplasmic membrane surface of RETINAL ROD CELLS and RETINAL CONE CELLS. Mutations in the ABCA4 gene are associated with Stargardt Disease 1, a hereditary juvenile form of MACULAR DEGENERATION.
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Classification
Broader headings
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Synonyms
7 entry terms
- ABCA4 Transporter
- ATP Binding Cassette Transporter, Sub-Family A, Member 4
- ATP Binding Cassette Transporter, Subfamily A, Member 4
- Retinal-Specific ATP-Binding Cassette Transporter
- Stargardt Disease Protein
- Retinal Specific ATP Binding Cassette Transporter
- Transporter, ABCA4
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2019 (2018)
MeSH Record
Previous Indexing
- ATP-Binding Cassette Transporters (1998-2017)
- Membrane Proteins (1988-2017)
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AMA Style
References
- National Library of Medicine. Subfamily A Member 4 ATP Binding Cassette Transporter. Medical Subject Headings (MeSH). 2026. Unique ID D000073882. http://id.nlm.nih.gov/mesh/2026/D000073882
- Subfamily A Member 4 ATP Binding Cassette Transporter. In: Wikidata. https://www.wikidata.org/wiki/Q24719772