Structured Summary
Abstract
An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison.
Chemical Identity
Chemical Information
- Molecular Formula
- C21H22N2O2
- Molecular Weight
- 334.4 g/mol
- CAS Registry No.
- 57-24-9
- IUPAC Name
- (4aR,5aS,8aR,13aS,15aS,15bR)-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one
- InChIKey
- QMGVPVSNSZLJIA-FVWCLLPLSA-N
- SMILES
- C1CN2CC3=CCO[C@H]4CC(=O)N5[C@H]6[C@H]4[C@H]3C[C@H]2[C@@]61C7=CC=CC=C75
- MeSH Unique ID
- D013331
- Source
- PubChem CID 441071
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
2 entry terms
- Strychnine Nitrate
- Nitrate, Strychnine
MeSH Record
Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
NUX VOMICA was heading 1963-78
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Strychnine. Medical Subject Headings (MeSH). 2026. Unique ID D013331. http://id.nlm.nih.gov/mesh/2026/D013331
- Strychnine. In: Wikipedia. https://en.wikipedia.org/wiki/Strychnine
- Strychnine. In: Wikidata. https://www.wikidata.org/wiki/Q194406
- Strychnine. In: PubChem Compound. CID 441071. https://pubchem.ncbi.nlm.nih.gov/compound/441071