Structured Summary
Abstract
Strains of MURINE LEUKEMIA VIRUS that are replication-defective and rapidly transforming. The envelope gene plays an essential role in initiating erythroleukemia (LEUKEMIA, ERYTHROBLASTIC, ACUTE), manifested by splenic foci, SPLENOMEGALY, and POLYCYTHEMIA. Spleen focus-forming viruses are generated by recombination with endogenous retroviral sequences.
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Classification
Broader headings
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Synonyms
8 entry terms
- SFFV
- Focus-Forming Virus, Spleen
- Focus-Forming Viruses, Spleen
- Spleen Focus Forming Viruses
- Spleen Focus-Forming Virus
- Friend spleen focus-forming virus
- Rauscher Spleen Focus-Forming Virus
- Friend spleen focus forming virus
MeSH Record
Aspects Covered
13 allowable subheadings
Indexed with the subheadings chemistry, classification, drug effects, enzymology, genetics, growth & development, immunology, isolation & purification, metabolism, pathogenicity, physiology, radiation effects, ultrastructure.
MeSH Record
Indexing Annotation
infection: coordinate IM with RETROVIRIDAE INFECTIONS (IM) + TUMOR VIRUS INFECTIONS (IM) + LEUKEMIA, EXPERIMENTAL (IM) or LEUKEMIA, ERYTHROBLASTIC, ACUTE (IM) (for spontaneous erythroleukemia)
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History Note
91(86); was see under MOUSE LEUKEMIA VIRUSES 1986-90
MeSH Record
Previous Indexing
- Friend Virus (1966-1985)
- Leukemia, Experimental (1966-1985)
- Mouse Leukemia Viruses (1966-1985)
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AMA Style
References
- National Library of Medicine. Spleen Focus-Forming Viruses. Medical Subject Headings (MeSH). 2026. Unique ID D013155. http://id.nlm.nih.gov/mesh/2026/D013155
- Spleen Focus-Forming Viruses. In: Wikidata. https://www.wikidata.org/wiki/Q68760472