Chemicals and Drugs

Spironolactone

A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)

Chemical Identity

Chemical Information

Molecular Formula
C24H32O4S
Molecular Weight
416.6 g/mol
CAS Registry No.
52-01-7
IUPAC Name
S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate
InChIKey
LXMSZDCAJNLERA-ZHYRCANASA-N
SMILES
CC(=O)S[C@@H]1CC2=CC(=O)CC[C@@]2([C@@H]3[C@@H]1[C@@H]4CC[C@]5([C@]4(CC3)C)CCC(=O)O5)C
MeSH Unique ID
D013148
Source
PubChem CID 5833

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

32 entry terms
  • Spirolactone
  • Veroshpiron
  • Verospirone
  • Aldactone
  • Aldactone A
  • Aquareduct
  • Duraspiron
  • Espironolactona Alter
  • Espironolactona Mundogen
  • Flumach
  • Frumikal
  • Jenaspiron
  • Novo-Spiroton
  • Practon
  • SC-9420
  • Spiractin
  • Spiro L.U.T.
  • Spiro Von Ct
  • Spirobeta
  • Spirogamma
  • Spirolang
  • Spirono-Isis
  • Spironone
  • Spirospare
  • Verospiron
  • Ct, Spiro Von
  • Novo Spiroton
  • NovoSpiroton
  • SC 9420
  • SC9420
  • Spirono Isis
  • Von Ct, Spiro

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Hierarchy

Tree Numbers

  1. D02w.540w.679w
  2. D04w.210.500w.745.745w.855w

MeSH Record

NLM Classification

QV 160

AMA Style

References

  1. National Library of Medicine. Spironolactone. Medical Subject Headings (MeSH). 2026. Unique ID D013148. http://id.nlm.nih.gov/mesh/2026/D013148
  2. Spironolactone. In: Wikipedia. https://en.wikipedia.org/wiki/Spironolactone
  3. Spironolactone. In: Wikidata. https://www.wikidata.org/wiki/Q422188
  4. Spironolactone. In: PubChem Compound. CID 5833. https://pubchem.ncbi.nlm.nih.gov/compound/5833