Chemicals and Drugs

Sp7 Transcription Factor

An Sp transcription factor that contains three CYS2-HIS2 ZINC FINGERS. It binds to GC RICH SEQUENCES and performs an essential function in regulating gene expression for differentiation of OSTEOBLASTS. Mutations in the SP7 gene are associated with type 12 OSTEOGENESIS IMPERFECTA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An Sp transcription factor that contains three CYS2-HIS2 ZINC FINGERS. It binds to GC RICH SEQUENCES and performs an essential function in regulating gene expression for differentiation of OSTEOBLASTS. Mutations in the SP7 gene are associated with type 12 OSTEOGENESIS IMPERFECTA.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

2 entry terms
  • Osterix Protein
  • Transcription Factor, Sp7

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Transcription Factors (2003-2017)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.260w.522w.750.937
  2. D12.776w.930w.375w.750.937

AMA Style

References

  1. National Library of Medicine. Sp7 Transcription Factor. Medical Subject Headings (MeSH). 2026. Unique ID D000076182. http://id.nlm.nih.gov/mesh/2026/D000076182
  2. Sp7 Transcription Factor. In: Wikidata. https://www.wikidata.org/wiki/Q29876609