Chemicals and Drugs

Somatomedin Receptors

Cell surface receptors that bind somatomedins and trigger intracellular changes which influence the behavior of cells. Studies have disclosed two types of receptors for this family of peptide hormones. The type I receptor is homologous to the insulin receptor and has tyrosine kinase activity. The type II receptor is identical to the mannose-6-phosphate receptor which is important in trafficking of lysosomal enzymes.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Cell surface receptors that bind somatomedins and trigger intracellular changes which influence the behavior of cells. Studies have disclosed two types of receptors for this family of peptide hormones. The type I receptor is homologous to the insulin receptor and has tyrosine kinase activity. The type II receptor is identical to the mannose-6-phosphate receptor which is important in trafficking of lysosomal enzymes.

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Synonyms

9 entry terms
  • Insulin-Like Growth Factor Receptor
  • Insulin-Like Growth Factor Receptors
  • Receptors, Insulin-Like Growth Factors
  • Receptors, Somatomedin
  • Somatomedin Receptor
  • Insulin Like Growth Factor Receptor
  • Insulin Like Growth Factor Receptors
  • Receptor, Somatomedin
  • Receptors, Insulin Like Growth Factors

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Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

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Indexing Annotation

specifics are also available

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History Note

93; was INSULIN-LIKE GROWTH FACTOR RECEPTOR (NM) 1980-92; INSULIN-LIKE GROWTH FACTORS RECEPTORS was see RECEPTORS, SOMATOMEDIN 1993

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Previous Indexing

  • Receptors, Endogenous Substances (1980-1992)
  • Receptors, Insulin (1980-1989)

MeSH Hierarchy

Tree Number

  1. D12.776w.543w.750w.750w.400w.780w

AMA Style

References

  1. National Library of Medicine. Somatomedin Receptors. Medical Subject Headings (MeSH). 2026. Unique ID D017451. http://id.nlm.nih.gov/mesh/2026/D017451
  2. Somatomedin Receptors. In: Wikipedia. https://en.wikipedia.org/wiki/Somatomedin_receptor
  3. Somatomedin Receptors. In: Wikidata. https://www.wikidata.org/wiki/Q7559298