Structured Summary
Abstract
A high-affinity, ATP-binding, co-transporter for CARNITINE that is highly expressed in kidney, skeletal muscle, heart, and placental tissues. It transports one sodium ion with one carnitine molecule. It has a lower affinity for other organic cations and transports them independently of sodium. Mutations in the SLC22A5 gene are associated with systemic carnitine deficiency.
MeSH Record
Classification
Broader headings
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MeSH Record
Synonyms
11 entry terms
- High-Affinity Carnitine Transporter
- OCTN2 Protein
- Organic Cation-Carnitine Transporter 2
- SLC22A5 Protein
- Sodium-Dependent Carnitine Cotransporter
- Carnitine Cotransporter, Sodium-Dependent
- Carnitine Transporter, High-Affinity
- High Affinity Carnitine Transporter
- Organic Cation Carnitine Transporter 2
- Sodium Dependent Carnitine Cotransporter
- Transporter, High-Affinity Carnitine
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2018
MeSH Record
Previous Indexing
- Carrier Proteins (1998-2017)
- Organic Cation Transport Proteins (2004-2017)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Solute Carrier Family 22 Member 5. Medical Subject Headings (MeSH). 2026. Unique ID D000074058. http://id.nlm.nih.gov/mesh/2026/D000074058
- Solute Carrier Family 22 Member 5. In: Wikidata. https://www.wikidata.org/wiki/Q7390798