Chemicals and Drugs

Soluble Guanylyl Cyclase

A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

14 entry terms
  • Nitric Oxide Receptor
  • Nitric Oxide Receptors
  • Nitric Oxide-Sensitive Guanylyl Cyclase
  • Receptor, Nitric Oxide
  • Soluble Guanylate Cyclase
  • Cyclase, Soluble Guanylate
  • Cyclase, Soluble Guanylyl
  • Guanylate Cyclase, Soluble
  • Guanylyl Cyclase, Soluble
  • Nitric Oxide Sensitive Guanylyl Cyclase
  • Oxide Receptor, Nitric
  • Oxide Receptors, Nitric
  • Soluble Guanylyl Cyclase, alpha Subunit
  • Soluble Guanylyl Cyclase, beta Subunit

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017 (2016)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.520w.650.600w.750w
  2. D12.776w.476.350w.500w

AMA Style

References

  1. National Library of Medicine. Soluble Guanylyl Cyclase. Medical Subject Headings (MeSH). 2026. Unique ID D000071756. http://id.nlm.nih.gov/mesh/2026/D000071756
  2. Soluble Guanylyl Cyclase. In: Wikipedia. https://en.wikipedia.org/wiki/Soluble_guanylyl_cyclase
  3. Soluble Guanylyl Cyclase. In: Wikidata. https://www.wikidata.org/wiki/Q7558945