Diseases

Sneddon Syndrome

A systemic non-inflammatory arteriopathy primarily of middle-aged females characterized by the association of LIVEDO RETICULARIS, multiple thrombotic CEREBRAL INFARCTION; CORONARY DISEASE, and HYPERTENSION. Elevation of antiphospholipid antibody titers (see also ANTIPHOSPHOLIPID SYNDROME), cardiac valvulopathy, ISCHEMIC ATTACK, TRANSIENT; SEIZURES; DEMENTIA; and chronic ischemia of the extremities may also occur. Pathologic examination of affected arteries reveals non-inflammatory adventitial fibrosis, thrombosis, and changes in the media (From Jablonski, Dictionary of Syndromes & Eponymic Diseases, 2d ed; Adams et al., Principles of Neurology, 6th ed, p861; Arch Neurol 1997 Jan;54(1):53-60). Mutations in the CECR1 gene (ADA2 protein, human) are associated with Sneddon syndrome.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A systemic non-inflammatory arteriopathy primarily of middle-aged females characterized by the association of LIVEDO RETICULARIS, multiple thrombotic CEREBRAL INFARCTION; CORONARY DISEASE, and HYPERTENSION. Elevation of antiphospholipid antibody titers (see also ANTIPHOSPHOLIPID SYNDROME), cardiac valvulopathy, ISCHEMIC ATTACK, TRANSIENT; SEIZURES; DEMENTIA; and chronic ischemia of the extremities may also occur. Pathologic examination of affected arteries reveals non-inflammatory adventitial fibrosis, thrombosis, and changes in the media (From Jablonski, Dictionary of Syndromes & Eponymic Diseases, 2d ed; Adams et al., Principles of Neurology, 6th ed, p861; Arch Neurol 1997 Jan;54(1):53-60). Mutations in the CECR1 gene (ADA2 protein, human) are associated with Sneddon syndrome.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

6 entry terms
  • Livedo Reticularis And Cerebrovascular Accidents
  • Livedo Reticularis, Systemic Involvement
  • Sneddon-Champion Syndrome
  • Sneddon Champion Syndrome
  • Syndrome, Sneddon
  • Syndrome, Sneddon-Champion

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

Indexing Annotation

do not confuse with SNEDDON-WILKINSON DISEASE see SKIN DISEASES, VESICULOBULLOUS

MeSH Record

History Note

1996

MeSH Record

Previous Indexing

  • Cerebrovascular Disorders (1983-1995)
  • Skin (1979-1983)
  • Skin Diseases, Vascular (1993-1995)

MeSH Hierarchy

Tree Numbers

  1. C10w.228w.140w.300w.750w
  2. C14w.907w.253w.774w
  3. C17.800w.862.775w

AMA Style

References

  1. National Library of Medicine. Sneddon Syndrome. Medical Subject Headings (MeSH). 2026. Unique ID D018860. http://id.nlm.nih.gov/mesh/2026/D018860
  2. Sneddon Syndrome. In: Wikipedia. https://en.wikipedia.org/wiki/Sneddon%27s_syndrome
  3. Sneddon Syndrome. In: Wikidata. https://www.wikidata.org/wiki/Q684840