Chemicals and Drugs

Small Nucleolar RNA

Small nuclear RNAs that are involved in the processing of pre-ribosomal RNA in the nucleolus. Box C/D containing snoRNAs (U14, U15, U16, U20, U21 and U24-U63) direct site-specific methylation of various ribose moieties. Box H/ACA containing snoRNAs (E2, E3, U19, U23, and U64-U72) direct the conversion of specific uridines to pseudouridine. Site-specific cleavages resulting in the mature ribosomal RNAs are directed by snoRNAs U3, U8, U14, U22 and the snoRNA components of RNase MRP and RNase P.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Small nuclear RNAs that are involved in the processing of pre-ribosomal RNA in the nucleolus. Box C/D containing snoRNAs (U14, U15, U16, U20, U21 and U24-U63) direct site-specific methylation of various ribose moieties. Box H/ACA containing snoRNAs (E2, E3, U19, U23, and U64-U72) direct the conversion of specific uridines to pseudouridine. Site-specific cleavages resulting in the mature ribosomal RNAs are directed by snoRNAs U3, U8, U14, U22 and the snoRNA components of RNase MRP and RNase P.

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Synonyms

2 entry terms
  • RNA, Small Nucleolar
  • snoRNA

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2000

MeSH Record

Previous Indexing

  • Cell Nucleolus (1975-1999)
  • RNA (1975-1985)
  • RNA, Small Nuclear (1986-1999)

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AMA Style

References

  1. National Library of Medicine. Small Nucleolar RNA. Medical Subject Headings (MeSH). 2026. Unique ID D020537. http://id.nlm.nih.gov/mesh/2026/D020537
  2. Small Nucleolar RNA. In: Wikipedia. https://en.wikipedia.org/wiki/Small_nucleolar_RNA
  3. Small Nucleolar RNA. In: Wikidata. https://www.wikidata.org/wiki/Q284416