Diseases

Small Fiber Neuropathy

Disorder of the peripheral nerves that primarily impair small nerve fibers. The affected small nerve fibers include myelinated A-delta fibers (see A FIBERS) and unmyelinated C FIBERS. Because these small fibers innervate skin and help control autonomic function, their neuropathy presents with neuropathic pain, reduced thermal and pain sensitivity, and autonomic dysfunction (e.g. abnormal sweating or facial flushing). Small fiber neuropathy can be idiopathic or associated with underlying diseases (e.g., AMYLOIDOSIS; DIABETES MELLITUS; SARCOIDOSIS; or VASCULITIS).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Disorder of the peripheral nerves that primarily impair small nerve fibers. The affected small nerve fibers include myelinated A-delta fibers (see A FIBERS) and unmyelinated C FIBERS. Because these small fibers innervate skin and help control autonomic function, their neuropathy presents with neuropathic pain, reduced thermal and pain sensitivity, and autonomic dysfunction (e.g. abnormal sweating or facial flushing). Small fiber neuropathy can be idiopathic or associated with underlying diseases (e.g., AMYLOIDOSIS; DIABETES MELLITUS; SARCOIDOSIS; or VASCULITIS).

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

8 entry terms
  • Small Fibre Neuropathy
  • Small Nerve Fiber Neuropathy
  • Neuropathies, Small Fiber
  • Neuropathies, Small Fibre
  • Neuropathy, Small Fiber
  • Neuropathy, Small Fibre
  • Small Fiber Neuropathies
  • Small Fibre Neuropathies

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

2017; use ERYTHROMELALGIA 2014-2016

MeSH Hierarchy

Tree Number

  1. C10w.668w.829w.860w

AMA Style

References

  1. National Library of Medicine. Small Fiber Neuropathy. Medical Subject Headings (MeSH). 2026. Unique ID D000071075. http://id.nlm.nih.gov/mesh/2026/D000071075
  2. Small Fiber Neuropathy. In: Wikipedia. https://en.wikipedia.org/wiki/Small_fiber_neuropathy
  3. Small Fiber Neuropathy. In: Wikidata. https://www.wikidata.org/wiki/Q2642518