Chemicals and Drugs

Sitagliptin Phosphate

A pyrazine-derived DIPEPTIDYL-PEPTIDASE IV INHIBITOR and HYPOGLYCEMIC AGENT that increases the levels of the INCRETIN hormones GLUCAGON-LIKE PEPTIDE-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). It is used in the treatment of TYPE 2 DIABETES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A pyrazine-derived DIPEPTIDYL-PEPTIDASE IV INHIBITOR and HYPOGLYCEMIC AGENT that increases the levels of the INCRETIN hormones GLUCAGON-LIKE PEPTIDE-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). It is used in the treatment of TYPE 2 DIABETES.

Chemical Identity

Chemical Information

Molecular Formula
C16H15F6N5O
Molecular Weight
407.31 g/mol
CAS Registry No.
486460-32-6
IUPAC Name
(3R)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
InChIKey
MFFMDFFZMYYVKS-SECBINFHSA-N
SMILES
C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N
MeSH Unique ID
D000068900
Source
PubChem CID 4369359

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

17 entry terms
  • Sitagliptin Monophosphate Monohydrate
  • Sitagliptin Phosphate Monohydrate
  • Monohydrate, Sitagliptin Monophosphate
  • Monohydrate, Sitagliptin Phosphate
  • Monophosphate Monohydrate, Sitagliptin
  • Phosphate Monohydrate, Sitagliptin
  • Phosphate, Sitagliptin
  • 4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine
  • Januvia
  • MK 0431
  • MK-0431
  • MK0431
  • Sitagliptin
  • Sitagliptin Phosphate Anhydrous
  • 0431, MK
  • Anhydrous, Sitagliptin Phosphate
  • Phosphate Anhydrous, Sitagliptin

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2016 (2005)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.129w.799w.725w
  2. D03w.383.679.875w

AMA Style

References

  1. National Library of Medicine. Sitagliptin Phosphate. Medical Subject Headings (MeSH). 2026. Unique ID D000068900. http://id.nlm.nih.gov/mesh/2026/D000068900
  2. Sitagliptin Phosphate. In: Wikipedia. https://en.wikipedia.org/wiki/Sitagliptin
  3. Sitagliptin Phosphate. In: Wikidata. https://www.wikidata.org/wiki/Q419832
  4. Sitagliptin Phosphate. In: PubChem Compound. CID 4369359. https://pubchem.ncbi.nlm.nih.gov/compound/4369359