Phenomena and Processes

Single-Stranded Conformational Polymorphism

Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.

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Synonyms

8 entry terms
  • Polymorphism, Single-Stranded Conformational
  • SSCP
  • Conformational Polymorphism, Single-Stranded
  • Conformational Polymorphisms, Single-Stranded
  • Polymorphism, Single Stranded Conformational
  • Polymorphisms, Single-Stranded Conformational
  • Single Stranded Conformational Polymorphism
  • Single-Stranded Conformational Polymorphisms

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

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Indexing Annotation

POLYMORPHISM, SINGLE NUCLEOTIDE is also available

MeSH Record

History Note

1995

MeSH Record

Previous Indexing

  • Polymorphism (Genetics) (1990-1994)

MeSH Hierarchy

Tree Number

  1. G05.365w.795w.600w

AMA Style

References

  1. National Library of Medicine. Single-Stranded Conformational Polymorphism. Medical Subject Headings (MeSH). 2026. Unique ID D018807. http://id.nlm.nih.gov/mesh/2026/D018807
  2. Single-Stranded Conformational Polymorphism. In: Wikipedia. https://en.wikipedia.org/wiki/Single-strand_conformation_polymorphism
  3. Single-Stranded Conformational Polymorphism. In: Wikidata. https://www.wikidata.org/wiki/Q1788683