Chemicals and Drugs

Sincalide

An octapeptide hormone present in the intestine and brain. When secreted from the gastric mucosa, it stimulates the release of bile from the gallbladder and digestive enzymes from the pancreas.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An octapeptide hormone present in the intestine and brain. When secreted from the gastric mucosa, it stimulates the release of bile from the gallbladder and digestive enzymes from the pancreas.

Chemical Identity

Chemical Information

Molecular Formula
C49H62N10O16S3
Molecular Weight
1143.3 g/mol
CAS Registry No.
25126-32-3
IUPAC Name
(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1-oxo-3-(4-sulfooxyphenyl)propan-2-yl]amino]-4-oxobutanoic acid
InChIKey
IZTQOLKUZKXIRV-YRVFCXMDSA-N
SMILES
CSCC[C@@H](C(=O)NCC(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N)NC(=O)[C@H](CC4=CC=C(C=C4)OS(=O)(=O)O)NC(=O)[C@H](CC(=O)O)N
MeSH Unique ID
D012844
Source
PubChem CID 9833444

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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MeSH Record

See Also

MeSH Record

Synonyms

15 entry terms
  • CCK-8
  • CCK-OP
  • Cholecystokinin Octapeptide
  • Cholecystokinin Pancreozymin C-Terminal Octapeptide
  • H-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2
  • OP-CCK
  • Syncalide
  • Cholecystokinin Pancreozymin C Terminal Octapeptide
  • Kinevac
  • SQ-19,844
  • SQ-19844
  • SQ 19,844
  • SQ 19844
  • SQ19,844
  • SQ19844

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

do not confuse with Sincaline ( = CHOLINE)

MeSH Record

History Note

84

MeSH Record

Previous Indexing

  • Cholecystokinin (1966-1983)
  • Oligopeptides (1973-1978)
  • Peptide Fragments (1979-1983)
  • Peptides (1966-1972)

MeSH Hierarchy

Tree Numbers

  1. D06.472w.317w.152w.700w
  2. D12.644w.120w.500w

AMA Style

References

  1. National Library of Medicine. Sincalide. Medical Subject Headings (MeSH). 2026. Unique ID D012844. http://id.nlm.nih.gov/mesh/2026/D012844
  2. Sincalide. In: Wikipedia. https://en.wikipedia.org/wiki/Sincalide
  3. Sincalide. In: Wikidata. https://www.wikidata.org/wiki/Q7521885
  4. Sincalide. In: PubChem Compound. CID 9833444. https://pubchem.ncbi.nlm.nih.gov/compound/9833444