Chemicals and Drugs

Simeprevir

Oral HCV-PROTEASE INHIBITOR effective against hepatitis C virus (HCV) serine protease NS3/4A. It is used in the treatment of chronic hepatitis C (Antivirals) genotype 1 infection in adults with compensated liver disease, including CIRRHOSIS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Oral HCV-PROTEASE INHIBITOR effective against hepatitis C virus (HCV) serine protease NS3/4A. It is used in the treatment of chronic hepatitis C (Antivirals) genotype 1 infection in adults with compensated liver disease, including CIRRHOSIS.

Chemical Identity

Chemical Information

Molecular Formula
C38H47N5O7S2
Molecular Weight
749.9 g/mol
CAS Registry No.
923604-59-5
IUPAC Name
(1R,4R,6S,7Z,15R,17R)-N-cyclopropylsulfonyl-17-[7-methoxy-8-methyl-2-(4-propan-2-yl-1,3-thiazol-2-yl)quinolin-4-yl]oxy-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carboxamide
InChIKey
JTZZSQYMACOLNN-VDWJNHBNSA-N
SMILES
CC1=C(C=CC2=C1N=C(C=C2O[C@@H]3C[C@@H]4[C@@H](C3)C(=O)N(CCCC/C=C\[C@@H]5C[C@]5(NC4=O)C(=O)NS(=O)(=O)C6CC6)C)C7=NC(=CS7)C(C)C)OC
MeSH Unique ID
D000069616
Source
PubChem CID 24873435

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

10 entry terms
  • N-(17-(2-(4-isopropylthiazole-2-yl)-7-methoxy-8-methylquinolin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo(13.3.0.04,6)octadec-7-ene-4-carbonyl)(cyclopropyl)sulfonamide
  • Olysio
  • TMC 435
  • TMC 435350
  • TMC-435
  • TMC-435350
  • TMC435
  • TMC435350
  • 435, TMC
  • 435350, TMC

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2016 (2008)

MeSH Hierarchy

Tree Numbers

  1. D02w.886w.590w.700w.700w
  2. D03w.633.300.819w

AMA Style

References

  1. National Library of Medicine. Simeprevir. Medical Subject Headings (MeSH). 2026. Unique ID D000069616. http://id.nlm.nih.gov/mesh/2026/D000069616
  2. Simeprevir. In: Wikipedia. https://en.wikipedia.org/wiki/Simeprevir
  3. Simeprevir. In: Wikidata. https://www.wikidata.org/wiki/Q7517689
  4. Simeprevir. In: PubChem Compound. CID 24873435. https://pubchem.ncbi.nlm.nih.gov/compound/24873435