Structured Summary
Abstract
A hydrazone and pyridazine derivative; the levo-form is a phosphodiesterase III inhibitor, calcium-sensitizing agent, and inotropic agent that is used in the treatment of HEART FAILURE.
Chemical Identity
Chemical Information
- Molecular Formula
- C14H12N6O
- Molecular Weight
- 280.28 g/mol
- CAS Registry No.
- 131741-08-7
- IUPAC Name
- 2-[[4-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenyl]hydrazinylidene]propanedinitrile
- InChIKey
- WHXMKTBCFHIYNQ-UHFFFAOYSA-N
- SMILES
- CC1CC(=O)NN=C1C2=CC=C(C=C2)NN=C(C#N)C#N
- MeSH Unique ID
- D000077464
- Source
- PubChem CID 60867
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
8 entry terms
- ((4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrazono)propanedinitrile
- Dextrosimendan
- Levosimendan
- OR 1259
- OR-1259
- OR-1855
- Simadax
- OR 1855
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2019 (1992)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Simendan. Medical Subject Headings (MeSH). 2026. Unique ID D000077464. http://id.nlm.nih.gov/mesh/2026/D000077464
- Simendan. In: Wikidata. https://www.wikidata.org/wiki/Q27256351
- Simendan. In: PubChem Compound. CID 60867. https://pubchem.ncbi.nlm.nih.gov/compound/60867