Anatomy

Shelterin Complex

A TELOMERE cap complex consisting of telomere-specific proteins in association with telomeric DNA such as telomeric dsDNA-sDNA junction. They are involved in the protection of chromosome ends and TELOMERASE regulation and play a role in CELLULAR SENESCENCE and ageing-related pathology. In general it consists of six mostly TELOMERE-BINDING PROTEINS (POT1, RAP1, TIN2, TPP1, TRF1, and TRF2).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A TELOMERE cap complex consisting of telomere-specific proteins in association with telomeric DNA such as telomeric dsDNA-sDNA junction. They are involved in the protection of chromosome ends and TELOMERASE regulation and play a role in CELLULAR SENESCENCE and ageing-related pathology. In general it consists of six mostly TELOMERE-BINDING PROTEINS (POT1, RAP1, TIN2, TPP1, TRF1, and TRF2).

MeSH Record

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MeSH Record

Synonyms

22 entry terms
  • POT1-TPP1 Shelterin Complex
  • Telomere POT1-TPP1 Complex
  • Telosome
  • Complex, POT1-TPP1 Shelterin
  • Complex, Shelterin
  • Complex, Telomere POT1-TPP1
  • POT1 TPP1 Shelterin Complex
  • POT1-TPP1 Complex, Telomere
  • Shelterin Complex, POT1-TPP1
  • Telomere POT1 TPP1 Complex
  • Telosomes
  • CST Complex
  • Ctc1-Stn1-Ten1 Complex
  • Telomere Cap Complex
  • Telomeric Capping Complex
  • Telomeric Stn1-Ten1 Capping Complex
  • Capping Complex, Telomeric
  • Complex, CST
  • Complex, Ctc1-Stn1-Ten1
  • Complex, Telomeric Capping
  • Ctc1 Stn1 Ten1 Complex
  • Telomeric Stn1 Ten1 Capping Complex

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2022

MeSH Record

Previous Indexing

  • Telomere-Binding Proteins (2005-2021)

MeSH Hierarchy

Tree Numbers

  1. A11w.284w.430w.106w.279.345.190w.160.845w.500w
  2. D05.500w.918w
  3. D12.776w.260w.735w.625w
  4. D12.776w.660w.235.700w.625w
  5. D12.776w.664w.981w
  6. G05.360w.160.845w.500w

AMA Style

References

  1. National Library of Medicine. Shelterin Complex. Medical Subject Headings (MeSH). 2026. Unique ID D000089804. http://id.nlm.nih.gov/mesh/2026/D000089804
  2. Shelterin Complex. In: Wikipedia. https://en.wikipedia.org/wiki/Shelterin
  3. Shelterin Complex. In: Wikidata. https://www.wikidata.org/wiki/Q3959366