Chemicals and Drugs

Sex Hormone-Binding Globulin

A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.

MeSH Record

Classification

Broader headings

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MeSH Record

See Also

MeSH Record

Synonyms

10 entry terms
  • Sex Steroid-Binding Protein
  • Testosterone-Estradiol Binding Globulin
  • Binding Globulin, Testosterone-Estradiol
  • Globulin, Sex Hormone-Binding
  • Globulin, Testosterone-Estradiol Binding
  • Hormone-Binding Globulin, Sex
  • Sex Hormone Binding Globulin
  • Sex Steroid Binding Protein
  • Steroid-Binding Protein, Sex
  • Testosterone Estradiol Binding Globulin

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

does not refer to all sex hormones: refers to a specific protein in the blood binding only testosterone or estradiol; for other sex hormone-binding globulins consider ANDROGEN-BINDING PROTEIN & PROGESTERONE-BINDING GLOBULIN

MeSH Record

History Note

77; SEX STEROID-BINDING PROTEIN was SEX-STEROID-BINDING PROTEIN (NM) 1981-91; ESTRADIOL-BINDING GLOBULIN & TESTOSTERONE-BINDING GLOBULIN were see SEX HORMONE-BINDING GLOBULIN 1977-92

MeSH Record

Previous Indexing

  • Beta Globulins (1974-1976)
  • Carrier Proteins (1971-1991)
  • Glycoproteins (1974-1975)
  • Protein Binding (1974-1975)
  • Sex Hormones (1974-1976)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.124w.790.223w.800w
  2. D12.776w.157w.762w
  3. D12.776w.377w.715.182w.800w

AMA Style

References

  1. National Library of Medicine. Sex Hormone-Binding Globulin. Medical Subject Headings (MeSH). 2026. Unique ID D012738. http://id.nlm.nih.gov/mesh/2026/D012738
  2. Sex Hormone-Binding Globulin. In: Wikipedia. https://en.wikipedia.org/wiki/Sex_hormone%E2%80%93binding_globulin
  3. Sex Hormone-Binding Globulin. In: Wikidata. https://www.wikidata.org/wiki/Q419613