Chemicals and Drugs

Serotonin Plasma Membrane Transport Proteins

Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of serotonergic neurons. They are different than SEROTONIN RECEPTORS, which signal cellular responses to SEROTONIN. They remove SEROTONIN from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. Regulates signal amplitude and duration at serotonergic synapses and is the site of action of the SELECTIVE SEROTONIN REUPTAKE INHIBITORS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of serotonergic neurons. They are different than SEROTONIN RECEPTORS, which signal cellular responses to SEROTONIN. They remove SEROTONIN from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. Regulates signal amplitude and duration at serotonergic synapses and is the site of action of the SELECTIVE SEROTONIN REUPTAKE INHIBITORS.

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See Also

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Synonyms

22 entry terms
  • 5-Hydroxytryptamine Plasma Membrane Transport Protein
  • Neurotransmitter Transport Proteins, Serotonin-Specific
  • Neurotransmitter Transporters, Serotonin-Specific
  • SERT Proteins
  • Serotonin Plasma Membrane Transporter Proteins
  • Serotonin Transporter
  • 5 Hydroxytryptamine Plasma Membrane Transport Protein
  • Neurotransmitter Transport Proteins, Serotonin Specific
  • Neurotransmitter Transporters, Serotonin Specific
  • Serotonin-Specific Neurotransmitter Transporters
  • 5HT Transporter
  • Platelet Serotonin Transporter
  • SLC6A4 Protein
  • Serotonectin
  • Serotonin Transporter, Platelets
  • Sodium-Dependent Serotonin Transporter
  • Solute Carrier Family 6, Member 4 Protein
  • Platelets Serotonin Transporter
  • Serotonin Transporter, Platelet
  • Serotonin Transporter, Sodium-Dependent
  • Sodium Dependent Serotonin Transporter
  • Transporter, Sodium-Dependent Serotonin

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2006(1992)

MeSH Record

Previous Indexing

  • Carrier Proteins (1992-2004)
  • Membrane Glycoproteins (1992-2005)
  • Membrane Transport Proteins (2005)
  • Nerve Tissue Proteins (1992-2005)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.530w.450w.625w.311
  2. D12.776w.157w.530w.562w.374.875
  3. D12.776w.157w.530w.937w.624
  4. D12.776w.543w.585w.450w.625w.374
  5. D12.776w.543w.585w.562w.374.875
  6. D12.776w.543w.585w.937w.747

AMA Style

References

  1. National Library of Medicine. Serotonin Plasma Membrane Transport Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D050486. http://id.nlm.nih.gov/mesh/2026/D050486
  2. Serotonin Plasma Membrane Transport Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q83164018